The Hidden Link between Chronic Inflammation & Cancer Published by Scientists

Advertisement

The inflammation is one of the the majority ordinary responses of the body to a threat whose origin unknown the circulation of blood to the affected area in order to isolate and destroy the attacking agent and repair the damage caused altered zone. The problem is that in many cases the attacker is imaginary or inconsistent response, causing some of the most common diseases like arthritis, the tuberculosis, the hepatitis, and other diseases that have the suffix it is in chronic inflammatory diseases immune cells produce highly reactive molecules containing oxygen and nitrogen and can damage DNA. The inflammation also stimulates cell division.

The hidden link cancer

Biologists have theorized the hypothesis that this simultaneous process -Damage CELLULAR DNA and dissection could significantly increase the possibility of cancer appear, as long as the cells divide they are more vulnerable to mutations caused by DNA damage . That is why, for example, a person suffering from colitis has more chance of getting colon cancer. The problem is that until now there was the technology needed to test this in an animal model that could be trusted. You have to have the right tools and so far simply not had. You have to control the onset of inflammation, you have to create markers that signal the DNA damage, you can see on the fabric, and you need a reader to observe mutations.

The dangers of chronic inflammation

To perform the experiment the scientists first had to create a mouse in which they could observe mutations in DNA. Specifically, the cells in the pancreas of these laboratory mice lit when a mutation occurred, a flash that could be seen with an ordinary microscope. Thanks to these mice, scientists could develop the experiment, inducing an inflammation of the pancreas and observing the resulting mutations. The time between the appearance of lesions in DNA and cell division functions as a defense mechanism against mutations, but does not work if the inflammation is chronic

When inflammation occurred in short bursts, with a week or more apart, no increase was not observed in mutations. However, when inflammation was induced with a few days apart, the number of mutations increased significantly. This finding reinforces which previous studies had shown pancreas: the cell division does not begin until several days after inflammation occur, whereas most of the DNA damage occurs immediately. DNA lesions are easily repaired without cancer could because mutations occur, but if the irritation is continuous and the damage occurs while increases cell division, multiply mutations. Then we have all the papers end up suffering from cancer.

Engelward believes that the time between the appearance of lesions in DNA and cell division functions as a defense mechanism against mutations, but is insufficient if we suffer severe acute attacks of inflammation followed or, even worse, if this is kept in time as in chronic inflammatory diseases, which many people, suffer for years. Pancreatitis, chronic inflammation of the pancreas, increases the risk of cancer in the body. Pancreatitis, chronic inflammation of the pancreas, increases the risk of cancer in the body.

A conspiracy that increases cancer formation

In the second part of the experiment, MIT scientists studied the effects caused in mice exposure to alkylating agents such as free radicals or carbenos-, substances in food, cosmetics or pollution (and also in certain standard chemotherapy drugs) that cause DNA damage. These alkylating agents induced lesions are easily repairable but after the experiment, Engelward and colleagues found that in inflamed tissues, where cells divide more rapidly, the injury resulting from these mutations also accumulate faster.

There are things that people with chronic tenderness can do to avoid exposure to problematic substances, such as limiting the use of certain foods that cause DNA damage In short, people with chronic inflammation not only have a much greater chance of developing malignant mutations also are much more vulnerable to carcinogens to which we are exposed worldwide. These findings suggest that chronic inflammation causes an increase in injuries and proliferation of DNA, jointly conspire to increase the chances of developing cancer explains Peter McKinnon , professor of genetics and tumor biology at St. Jude Children’s Research Hospital, who was not involved in this study.

The research has two important implications: first, warns that people with chronic inflammation are more vulnerable to common carcinogens, so they should be more careful with them. “Chronic inflammation causes a lot of cancers such as pancreatic, esophageal, and liver and the colon,” says Engelward. “But there are things that these patients can do to avoid exposure to problematic substances, such as limiting, for example, the consumption of certain foods that cause DNA damage.

Moreover, the study could have implications for the growth of new drugs to treat cancer, since much of chemotherapy works by damaging DNA. Cancer cells often divide, making them more susceptible to mutations, which can help them survive chemotherapy, since some of these mutations confer drug resistance. According Engelward, the study reinforces the idea that it is necessary to increase the toxicity of chemotherapy designed to damage DNA through new combinations of drugs that effectively suppress tumor series.

 

Advertisement